The angle of attack and sideslip signal is an important parameter of the flight control system. According to the characteristics of the angle of attack sensors on both sides of the fuselage that are affected by the angle of sideslip, a pair of angle of attack sensors are used to calculate the angle of attack and sideslip.Wind tunnel tests were carried out on the front fuselage model of a large amphibious aircraft, and angle of attack sensors were installed symmetrically at both sides of the fuselageto study the variation of the measured values of the two sides of the angle of attack sensors with the angle of attack and sideslip angle of the model, the angles of attack and sideslip are calculated from the mean and difference of the measurements on the left and right sides. The scheme is verified by flight test. The preliminary flight test results show that it is feasible to calculate the angle of attack and sideslip angle by using the angle of attack sensors on the left and right sides of the fuselage.