Full scale aircraft fatigue test is a large, complex and long-lasting ground verification test required by the specification to sustain Aircraft Structural Integrity Program and meet airworthiness requirements. Several important issues of full scale aircraft fatigue test, such as test objective, load spectrum, duration and scatter factor, are the key concern and widely discussed by aircraft designer/engineer. The scatter factor is also a problem studied by scholars. In recent years, our team has completed full scale fatigue tests of several aircraft programs. This paper introduces the study and understanding of the above-mentioned issues, compares the fatigue design and full scale fatigue tests of several fighter jets in China and Europe/America, and puts forward some practical engineering suggestions for full scale aircraft fatigue test. The research in this paper can provide important reference for other full scale aircraft fatigue tests.