Aviation Fuel pump faces the flow-induced noise problem which affects the unit operation stability and staff’s working security. To solve these problems, the noise reduction technique for fuel pump is introduced in this case. Firstly, noise data of fuel pump are acquired during the on-land system test of air plane. The amplitude and frequency are analyzed. Then, numerical simulation is conducted to understand the flow regime in the fuel pump. Results show that the main reason of flow-induced noise is the pressure fluctuation caused by rotor-stator interaction between impeller and guide vane. Finally, optimizations are done for impeller and guide vane of fuel pump. Numerical and experimental results find that the pressure fluctuation can be reduced by increasing the impeller and vane blade number and applying the alternate loading technique. After optimization, the noise of pump decreases by 6.5 dB. The results and conclusions can be a good reference for similar fuel pump’s optimization cases.