The Hybrid-Wing-Body(HWB) configuration is characterized with high cruising efficiency, large loading space, high structural efficiency and enough longitudinal stability. Compared with traditional configuration, the proportion of central body and inner wing section is larger, which provide sufficient optimization space for advanced ship-body design. These characters will comprehensively improve the seaworthiness of amphibious plane. Aimed to a wing-body configuration for a large amphibious aircraft based on the HWB concept, the aerodynamic performance design of high lift wings according to the requirements of lift and stall performance during takeoff and landing stages was carried out. The analysis results show that with the extension of stall point and the arrangement of nonlinear lift of airfoils, the stall angle of wing-body combination based on HWB configuration reaches 20°, while the maximum lift coefficient reaches 2.0. A reasonable stall-separation sequence between the root and tip of wing effectively and a gentle trailing-edge separation pattern are both realized, which ensures the aerodynamic safety during takeoff and landing.