Aluminum alloy manufactured by SLM (Selective Laser Melting) technology has been widely used in aerospace and other industries, but it has some defects such as gas pore, LOF (Lack of Fusion) and so on, which can seriously affect the fatigue performance, and there are few studies concerning its VHC fatigue properties and S-N curve so far. In this paper, the VHC fatigue properties of SLM manufactured TiB2 high-strength aluminum alloy and AlMgScZr high-strength aluminum alloy were studied, and the fatigue test up to 108 cycles has been completed. The S-N curves of the two materials were obtained, the fracture characteristics were analyzed, and the fatigue properties of the two alloys were compared with those of ordinary aluminum alloys. The results show that the fatigue property of AlMgScZr high strength aluminum alloy is slightly better than that of TiB2 high strength aluminum alloy. At the same time, the static strength and fatigue strength of two kinds of SLM aluminum alloy are higher than that of ordinary aluminum alloy, but the relative fatigue strength is worse than that of ordinary aluminum alloy.