Detailed research for wing aerodynamic characteristics of propeller slipstream at Low Reynolds number could contribute the mechanism study of low speed near space flow, and provide reliable aerodynamic results. The geometric model of single propeller with two-bladed is referred to a Solar-Powered UAV. High-quality structured grid is generated by ICEM software with two computational domains. Also, the grid application compatible boundary conditions employ sliding mesh method. It analyzes the development of propeller slipstream and unsteady aerodynamic characteristics of wing at Low Reynolds number propeller slipstream. Furthermore, it compares and analyzes the wing aerodynamic characteristics at different propeller positions. The results indicate that the propeller slipstream could significant change the surface pressure of the wing and the lift distribution along wingspan. Moreover, the results show that the propeller slipstream affects wing characteristic by changing the lift and drag. Meanwhile, the laminar separation bubble might be considerable prevented by the propeller slipstream.