To investigate the performance of combustion and flow characteristics of four-duct-annular advanced vortex combustor with flow guide vanes, the effects of different structure parameters of the flow guide vanes on flow fields, structure of vortices, the total pressure loss, combustion efficiency were numerically analyzed. The results show that the stable dual vortices structure is formed in the cavity, the stability of flame and the mixing of gas in the cavity are enhanced and the combustion efficiency is greatly increased. The structure parameter a/E influences the performance of the combustor significantly. With the increasing value of a/E, the combustion efficiency increases significantly, but the total pressure loss coefficient also increases simultaneously. When the value of b/H increases, the combustion efficiency and total pressure loss coefficient decrease simultaneously. The combustion efficiency and total pressure loss coefficient decrease first and then rise slightly with the increasing value of c/E. When a/E=0.3, b/H=0.4, c/L=0.2, the best characteristic of the combustor is achieved with the combustion efficiency 98.56%, the total pressure loss coefficient 3.194%.